New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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Applying one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our study pursuits include things like:
It had been only in the nineties though, when nanotechnology had Highly developed into a amount exactly where solitary molecules might be manipulated, that the 1st experimental devices started to look.
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
2007, initial authentic-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence duration of ends of microtubules; and settled the system of biosensing with carbon nanotubes
This yielded a breakthrough. In just just a few months, we were in the position to measure transportation by means of somebody solitary-walled carbon nanotube. Based on lower-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Engineering having an active investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly long (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
What distinguishes biology from chemistry is always that these components jointly make up a living process. The secret of claimed existence, I do think, lies inside the interactions, the interaction of Individuals molecules. The massive query with regard to the origin of existence remains unanswered. How did we ever evolve from uncomplicated molecules into the really complex techniques we see now? We have no idea. I need to ceesdekker.net operate on these kinds of massive, open up concerns.’
2011, initially in vitro measurements of transportation throughout one biomimetic nuclear pore advanced; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
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Very amazing, but that wasn’t really in which my desire lay. I desired to pioneer and I experienced the sensation that was no more possible, since the most attention-grabbing fundamental insights had by now been uncovered. But my field had formulated many fascinating new instruments to measure unique molecules. I decided that I needed to implement this to biology, to take a look at it from a physical perspective.’
An integrated microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
1999, 1st measurement of the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for any new Luttinger description of interacting electrons in nanotubes
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
The biophysicist from Delft – who has become The most cited experts from the Netherlands For several years – can take his accountability to contribute to the rationalization and popularisation of his get the job done for the border of physics and biology really significantly and frequently seems from the media; if not to discuss his work, then about the connection among science and his Christian faith.